What causes cell death in Parkinson's disease?
Identifieur interne : 000C21 ( Main/Exploration ); précédent : 000C20; suivant : 000C22What causes cell death in Parkinson's disease?
Auteurs : Amitabh Gupta [États-Unis] ; Valina L. Dawson [États-Unis] ; Ted M. Dawson [États-Unis]Source :
- Annals of Neurology [ 0364-5134 ] ; 2008-12.
Abstract
Currently, there is no proven neuroprotective or neurorestorative therapy for Parkinson's disease (PD). Several advances in the genetics of PD have created an opportunity to develop mechanistic‐based therapies that hold particular promise for identifying agents that slow and even halt the progression of PD, as well as restore function. Here we review many of the advances in the last decade regarding the identification of new targets for the treatment of PD based on understanding the molecular mechanisms of how mutations in genes linked to PD cause neurodegeneration. Ann Neurol 2008;64 (suppl):S3–S15
Url:
DOI: 10.1002/ana.21573
Affiliations:
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Several advances in the genetics of PD have created an opportunity to develop mechanistic‐based therapies that hold particular promise for identifying agents that slow and even halt the progression of PD, as well as restore function. Here we review many of the advances in the last decade regarding the identification of new targets for the treatment of PD based on understanding the molecular mechanisms of how mutations in genes linked to PD cause neurodegeneration. Ann Neurol 2008;64 (suppl):S3–S15</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Gupta, Amitabh" sort="Gupta, Amitabh" uniqKey="Gupta A" first="Amitabh" last="Gupta">Amitabh Gupta</name></region><name sortKey="Dawson, Ted M" sort="Dawson, Ted M" uniqKey="Dawson T" first="Ted M." last="Dawson">Ted M. 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